Antimony is usually mixed with other metals such as lead and zinc to form mixtures of metals called alloys. Toxicity can also result from repeated exposure to antimony in medications, such as tartar emetic (antimony and potassium tartrate), used to induce vomiting and in treatment of helminthic and fungal infestations. Its TLV is 0.5 mg/m , as for most antimony compounds. <]>>
Antimony trioxide has suspected carcinogenic potential for humans. Subchronic and chronic inhalation studies with rats and mice have demonstrated increased incidence of lung neoplasia following antimony trioxide exposure. 0. Another risk group for antimony exposure are patients suffering from schistosomiasis and leishmaniasis. 0000012712 00000 n
One compoundâantimony trioxideâis even believed to be carcinogenic, and antimony poisoning has also been known to lead to Adams-Stokes syndrome. Low doses cause headaches, nausea, dizziness and depression. Antimony trioxide TSCA 8(b) inventory: Antimony trioxide SARA 313 toxic chemical notification and release reporting: Antimony trioxide CERCLA: Hazardous substances. xref
The main signs are irritation of the respiratory tract and of the skin and a characteristic pneumoconiosis, which is visible on chest X-rays. Symptoms include an acrid metallic taste, cardiac failure, sweating, and vomiting about 30 min after ingestion. If the problem has been caused through the inhalation, ensure that the individual has fresh air to breathe.Â. A silt-loam soil (pH 7.0, background 0.005 mmol Sb kg−1) was amended with Sb2O3at various concentrations. Immediate steps should be taken to limit its spread to the environment. startxref
More information about reproductive toxicity here. Symptoms of Excessive Antimony Exposure and Antimony Toxicity. Occupational exposure of Antimony includes individuals working with brake pad systems for heavy weight vehicles and port workers who are exposed to traffic on a daily basis. [ … No other human health hazards were identified for antimony(III) oxide, and no risks to human health and the environment were identified from the production and use of antimony trioxide in daily life. It is insoluble in water. 1309-64-4 - GHPGOEFPKIHBNM-UHFFFAOYSA-N - Antimony trioxide - Similar structures search, synonyms, formulas, resource links, and other chemical information. It is insoluble in water. Exposure to antimony trioxide may increase the risk of cancer. Acute (short-term) exposure to antimony by inhalation in humans results in effects on the skin and eyes. 0000006747 00000 n
Antimony trioxide is on the Proposition 65 list because it can cause cancer. 0000000796 00000 n
: A860-100; A860-500 CAS-No 1309-64-4 Synonyms Antimony trioxide Recommended Use Laboratory chemicals. 0000003918 00000 n
Those who are exposed to low doses for over long periods of time, will also show the symptoms of poisoning as mentioned above. 0000003037 00000 n
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Antimony trioxide is used in the production of polyethylene terephthalate (PET) water bottles. �$�*���� �-F�|~9���sƄ�S}�[����Ɯ�(���yNz\F$>&���X&���gXd$8��p4���+7Z��6l[7��$\\����}[�۹���S%�n����Iġ���ݦ�)��jz�ߨU��J0�w������6�E�V$�������W����[��_]�ҁ? Antimony Review Pulmonary Toxicity Cancer Genotoxicity Mechanism ABSTRACT Although occupational exposure to antimony and its compounds can produce pulmonary toxicity, human car-cinogenic impacts have not been observed. The toxicity of antimony trioxide is topical because it is a likely byproduct of the combustion of some materials "fireproofed" with antimony compounds. Always consult with your doctor before making any decision affecting your health. endstream
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Antimony trioxide; CASRN 1309-64-4 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . Antimony is used as a part of the therapy for these conditions and can sometimes have toxic side effects that lead to pancreatitis and cardiotoxicity. Occupational exposure may cause respiratory irritation, pneumoconiosis, antimony spots on the skin and gastrointestinal symptoms. 0000002545 00000 n
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Antimony toxicity occurs either due to occupational exposure or during therapy. 0000001060 00000 n
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Antimony(III) oxide has suspected carcinogenic potential for humans. The information is not presented with the intention to treat or diagnose any disease or condition. Large doses cause vomiting, diarrhea, abdominal discomfort and tingling of the extremities. Introduction. This site is a comprehensive resource for information regarding heavy metal toxicity and chelation therapy. Includes washing the stomach with sterile or saltwater to remove poison. 0
Adequate magnesium, selenium, and methionine decrease the absorption and retention of antimony. The toxicity of antimony trioxide is topical because it is a likely byproduct of the combustion of some materials "fireproofed" with antimony compounds. Most commonly, the metal is used as a flame retardant in products as diverse as toys, car seat covers, engine covers for light aircraft, clothing for kids, and uniforms for fire fighters. The oxides of arsenic, antimony, and bismuth are comparable in their toxicity, but their volatilities differ widely. 0000005517 00000 n
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H��T]o�0}ϯ��I������-�2��QWk7�! It can also be found in foods such as meats, vegetables, seafood and tobacco. * Prolonged or repeated contact can cause ulcers or sores in the nose. It is brought into this country from other countries for processing. Antimony is a silvery-white metal that is found in the earth's crust. The primary hazard is the threat to the environment. Copyright © 2021 | WordPress Theme by MH Themes, Protocol for IV and Oral EDTA Chelation â Medical Review, FDA Public Health Advisory: Edetate Disodium, Antimony accumulates in adrenals, thyroid, kidney, liver, spleen, and bone, Binds to the good sulfhydryl detoxification chemicals groups. 0000001502 00000 n
Identification Product Name Antimony(III) oxide Cat No. 0000001141 00000 n
Over fifty people were "very sick" and treated in hospital after drinking lemonade contaminated with 13 mg/L antimony. The guidelines for maximum permissible levels of antimony in drinking water are as follows: Remove the individual from the toxic environment. are not met since there is an absence of consistent identifiable toxic effects other than the non-specific PSP overload, which is an adaptive response not triggering a STOT classification. ACGIH (2006) classified “antimony trioxide production” as a suspected human carcinogen (Group A2), although “antimony and compounds” was not similarly classified. Additionally, such individuals also suffer from hair loss and develop a scaly skin rash that called lichen planus. Antimony trioxide (Sb2O3) is a widely used chemical that can be emitted to soil. In long-term animal experiments, rats exposed to antimony trioxide via inhalation showed a high frequency of lung tumours. IRIS assessment development process. Hazard Summary. The major toxic side-effects of antimonials as a result of therapy are cardiotoxicity (~9% of patients) and pancreatitis, which is seen commonly in HIV and visceral leishmaniasis co-infections. Chronic poisoning by antimony trioxide is also rare. 0000004671 00000 n
1, 1A, or 1B. Antimony trioxide is a white crystalline solid. Chelation therapy with BAL, DMSA, or DMPS has been shown to improve antimony toxicity. We hope you find the information helpful in your journey to healing! Liver: USG Abdomen / Liver biopsy as clinically indicated to rule out internal damage. These alloys are used in lead storage batteries, solder, sheet and pipe metal, bearings, castings, type metal, ammunition, and pewter. Eye and eye lid inflammation (Conjuctivitis, , Keratitis). The oxides of arsenic, antimony, and bismuth are comparable in their toxicity, but their volatilities differ widely. However, the effects will vary depending upon the amount and period of exposure. A second group of people at risk for antimony exposure is patients suffering from schistosomiasis and leishmaniasis. Of exposure Research on cancer: A860-100 ; A860-500 CAS-No 1309-64-4 Synonyms antimony trioxide may increase the of. 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