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Antihistamines that can cause weight gain … Flonase is a brand … For children, weight gain … Nearly all types of antipsychotic medications—such as olanzapine, clozapine, and risperidone—cause weight gain, according to 2017 research published in the journal Neuropsychiatric … I did look it up and there seem to be a few studies that show correlation but not causation so 50% of people who take antihistamines are obese but not that antihistamines will cause weight gain in 50% of users. weight gain Other side effects not listed may also occur in some patients. Antihistamines can also make you feel tired and unmotivated to exercise. Essential oils (10) - … Few things are more difficult to address than weight gain—especially when it affects your child. My Dr. also stopped my prescription for nasal spray as my weight is a steady 135lbs and since taking flonase for 6 weeks I have gained TEN. 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