An ultrasound scan of the patient's abdomen showed a singleton, well grown, live pregnancy, Red degeneration primarily occurs secondary to venous thrombosis within the periphery of the tumor or rupture of intratumoral arteries 4. Submit. There may also experience some light bleeding as well as a mild fever, vomiting and nausea. Fibroids are noncancerous tumors that grow on or in the muscular walls of the uterus. If large enough, they may push on the bladder causing a frequent need to urinate. Fibroids may be. Done. Red degeneration of a fibroid typically occurs in pregnancy. Coronal If a fibroid grows quickly, blood vessels feeding the fibroid may not be able to grow fast enough to supply the new tissue with enough blood and oxygen. Its occurrence is even rare in nonpregnant woman. Was on a paracetamol IV and codeine for two days but now buscopan and have been discharged home. Seeing red degeneration in uterine fibroids in pregnancy: proceed with caution Ana Sofia Cerdeira, Mariana Tome, Niall Moore, Lee Lim A 32-year-old pregnant woman was admitted to our hospital at 18 weeks of gestation with a 5-day history of severe, sharp, and constant abdominal pain. It happens when fibroid grows beyond its limited blood supply. While fibroids are non-cancerous, they cause uncomfortable and often painful symptoms and can lead to infertility. Uterine fibroid degeneration occurs when a fibroid outgrows its limited blood supply. In addition to pelvic pain, red degeneration may cause a low-grade fever and a temporary elevation in white blood cell count, notes Cancer-Disease-Symptoms.org 4 . and several large uterine fibroids; no ovarian cysts were seen and there was nothing Fibroid in pregnancy is a relatively common complication, which aggravates pertaining to increase in size or red degeneration during pregnancy. This can trigger already present-fibroids to grow larger. Jan 14, 2016. Red Degeneration of Fibroids. fibroid (green arrowheads) and the fetus (encircled and red arrowhead; B). Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the uterus. Though fibroid degeneration does decrease the size of fibroids, it cannot manage them long-term — a degenerated fibroid is likely to expand and degenerate again. Red degeneration usually begins around 20 weeks and the pain can vary from no pain to severe pain around the fibroid as well as the lower back. Copyright © 2021 Elsevier Inc. except certain content provided by third parties. Ask doctors free. It started with a dull ache in my right side that turned to agony. concentration of C-reactive protein (35 mg/L). Most women have no symptoms while others may have painful or heavy periods. When the connecting blood vessels cannot provide enough oxygen to a fibroid, its cells begin to die, or degenerate. Cause of red degenation of fibroid Red degeneration occurs mainly in large fibroids and usually in later half of pregnancy or during puerperium. PATHOLOGY While the disease is spoken of as red degeneration, the color of the cut surface may vary from bright red to brown, or have a greenish, bluish or dirty gray appearance. On gross appearance, it resembles leiomyosarcoma, a malignant neoplasm of uterine smooth muscle. 15BMR65 For more. It is due to thrombosis of large veins in the tumor. They are estimated to affect 40–80% of women by age 50 years. uterus remained soft with no contractile activity and the fetal heart rate was normal. Please enter a term before submitting your search. Tumor is red/purple in color. Uterine fibroids: Pathogenesis and interactions with endometrium and endomyometrial junction. It was scary. On admission, Uterine fibroids can undergo hyaline, cystic, myxoid, and red degeneration. (29,30) Red degeneration describes the hemorrhagic necrosis of a rapidly enlarging fibroid due to venous thrombosis of peripheral vessels or rupture of supplying arteries. While many do not cause symptoms, some fibroids cause pain and bleeding. They will give you another scan at 36 weeks to see where the fibroid is (most fibroids move around and get pushed out of the way by a growing baby). A fibroid, or uterine leiomyoma, is a type of non-cancerous growth that commonly develops inside the womb, or uterus.Fibroid degeneration takes place when the fibroid has been increasing in size over a number of years, and its blood supply is no longer adequate to support the center of the tumor. Red degeneration may occur as the fibroid rapidly enlarges during pregnancy, outgrowing its blood supply and becoming ischaemic. Other times, the fibroid outgrows its blood supply, turns red and dies. Hello! Red degeneration is a common complication associated with fibroids during pregnancy. As many as 1 in 3 women will develop fibroids, which are non-cancerous growths that can grow in or around the womb. fibroid (green arrowheads) and the fetus (encircled and red arrowhead; A). When this happens, the cells of the fibroids begin to die; this process is called as fibroid degeneration. 3,4 Several factors make it difficult to assess the impact of fibroids on pregnancy outcome and to identify specific fibroid characteristics that are important. Degeneration is described as hyaline, myxomatous, calcific, cystic, fatty, red (usually only during pregnancy), or necrotic. Radiology, 164 (2): 375-380. Red degeneration is more likely to occur in larger fibroids (above 5 cm) during the second and third trimester of pregnancy. Although patients are often concerned about cancer in fibroids, sarcomatous change occurs in < 1% of patients. Most frequent complication of myoma during pregnancy. ... Degeneration is described as hyaline, myxomatous, calcific, cystic, fatty, red (usually only during pregnancy), or necrotic. {"url":"/signup-modal-props.json?lang=us\u0026email="}. Fibroids are common, benign smooth muscle tumours originating from uterine myometrial cells. Radiological and pathological characteristics of the lesions are summarized in Table 3. The gravid uterus was soft with a palpable mass at the fundus: Degeneration is the deteriorates of tissue function. "what happens during fibroid degeneration?and what are the signs of degeneration?" with a 5-day history of severe, sharp, and constant abdominal pain. Fibroids are typically benign growths that form in the uterus. 2. Something wrong? The Lancet Regional Health – Western Pacific, Advancing women in science, medicine and global health, Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial, Red degeneration in uterine fibroids complicates pregnancy, https://doi.org/10.1016/S0140-6736(19)32322-0, Seeing red degeneration in uterine fibroids in pregnancy: proceed with caution, View Large They may also cause pain during sex or lower back pain. However, many fibroids are small and asymptomatic. Pelvic pain. ADVERTISEMENT: Radiopaedia is free thanks to our supporters and advertisers. If this happens, the fibroid undergoes a process called degeneration, or … Image, Download Hi-res Urinary tract problems such as frequency, urgency, urinary incontinence, or hydronephrosis. Fibroid and Pregnancy Prevalence of fibroids in pregnancy is 18% based on 1st trimester USG Most of fibroids do not increase significantly in pregnancy. If the fibroids aggressively grow, they can degenerate, causing significant pain to the patient. If large enough, they may push on the bladder causing a frequent need to urinate. Degeneration, involving cell death, occurs inside the fibroid, and calcification, where calcium is deposited in the fibroid tissue, may be seen on an ultrasound scan. It contains a more recent bleeding component with T2-dephasing. They develop in women of reproductive age and are promoted and maintained by … Her vital signs were normal. Fibroids are commonly asymptomatic and may be identified incidentally by examination or investigation for gynaecological problems (such as failure to conceive) or during a routine pregnancy assessment. MRI images demonstrate a large T1 bright uterine mass compatible with a fibroid that has undergone red degeneration. Uterine fibroids are the single most common indication for hysterectomy. Red degeneration is a common complication associated with fibroids during pregnancy. I only had one episode of this though. I go in to the doctor and he confirms it is a fibroid ( I didn't even know I had them at the time) Ultrasound says I have 3 in … No extrauterine or intraperitoneal fluid collections. She had no significant red or carneous degeneration - an acute degenerative process caused by haemorrhage into the tumour; affects half of all fibroids during pregnancy ** If a fibroid grows quickly, blood vessels feeding the fibroid may not be able to grow fast enough to supply the new tissue with enough blood and oxygen. Most women have no symptoms while others may have painful or heavy periods. It happens when fibroid grows beyond its limited blood supply. to suggest an appendicitis. In pregnancy, fibroids can lead to complications such as placental abruption and increased caesarean section rates. This can trigger already present-fibroids to grow larger. I only had one episode of this though. there was no vaginal bleeding. When a fibroid degenerates, it shrinks back to a smaller size that its blood supply can support. Fibroid degeneration takes place when the fibroid has been increasing in size over a number of years, and its blood supply is no longer adequate to support the center of the tumor. T2-weighted MRI shows increased signal regions—red degeneration—within the fundal the woman looked pale and was in severe discomfort. Crown Copyright © 2019 Published by Elsevier Ltd. All rights reserved. Pregnancy and Fibroids The process of pregnancy stimulates estrogen production. Background: Red degeneration of fibroid is a rare event, but when it occurs, it is reported more often during pregnancy as an acute clinical presentation. 1,2 Symptomatic fibroids are associated with great costs to the patient and the healthcare system; it was estimated that uterine fibroids incurred a total direct cost of US$10.3 billion in the United States in one year alone. In some cases, it can lead to miscarriage. Uterine fibroids: Pathogenesis and interactions with endometrium and endomyometrial junction. Types of degeneration include hyaline degeneration, myxoid or cystic degeneration, necrotic degeneration, red (hemorrhagic) degeneration, calcification or fatty degeneration, and sarcomatous transformation (very rarely, <0.05 % of resected fibroids) . Red degeneration is a common complication associated with fibroids during pregnancy. There are three types of degeneration that happen in the fibroids. They are living tissue, requiring oxygen and nutrients to survivie and grow, supplied by blood vessels in an around the uterus. Primiparous woman in her 26th gestational week with known large uterine leiomyomas complained of a dull pain in the left lower quadrant. Top answers from doctors based on your search: Disclaimer. [3] 1. Fibroids cause blood clots novasure and fibroids,fibroid pneumonia when fibroids. Why leiomyomas are called fibroids: the central role of extracellular matrix in symptomatic women.. Semin Reprod Med. When fibroids bec… Location of the fibroid in the lower uterine segment predispose towards a higher frequency of Cesarean section by obstruction of the birth canal(15). On gross pathologic analysis, uterine leiomyomas are circumscribed with a solid rubbery firm texture and bulging cut surface ; they are generally white, but if degeneration is present, the color (red, brown, or yellow) and texture (edematous, fleshy, or obviously necrotic) may be different. Objective: Red degeneration (hemorrhagic infarction) of uterine leiomyoma can cause acute abdominal pain. had an acute appendicitis, an ovarian cyst torsion, or a threatened miscarriage. Her blood tests were unremarkable except for an increased Murray regards the color as due to the hemolytic action of lipoids. doi: 10.1055/s-0030-1251475 . A woman can have one uterine fibroid or many. 2010; 28 (3): p.169-179. medical history and prior to this pain, the pregnancy had been uneventful. I had red degeneration at 18 weeks and was given codeine for the pain and probably had about a week in bed recovering. Red degeneration refers to ischaemia, infarction and necrosis of the fibroid due to disrupted blood supply. Subscribe. Simply log in to access the full article, or register for free if you do not yet have a username and password. When blood supply is inadequate, its cells begin to die or degenerate—so whorled appearance of tumor change. Carneous degeneration is a subtype of hemorrhagic infarction of leiomyomas that often occurs during pregnancy. Edema is not a phenomenon of degeneration but is a common histopathologic finding (∼50% of cases). One of the main indicators of degenerating fibroid is an acute stabbing pain and swelling in the abdomen. It has a peculiar fishy odor; Occurs during Second half of pregnancy or puerperium. I had red degeneration at 18 weeks and was given codeine for the pain and probably had about a week in bed recovering. Red degeneration of uterine fibroids in pregnancy | Radiology Case | Radiopaedia.org. An MRI showed uterine fibroids (. If you were to look up red degeneration of fibroid you would see what I saw at my opening. "what happens during fibroid degeneration?and what are the signs of degeneration?" Symptoms of fibroids include: Heavy menstrual bleeding. Her Fibroid in pregnancy is a relatively common complication, which aggravates pertaining to increase in size or red degeneration during pregnancy. Red degeneration usually begins around 20 weeks and the pain can vary from no pain to severe pain around the fibroid as well as the lower back. They will give you another scan at 36 weeks to see where the fibroid is (most fibroids move around and get pushed out of the way by a growing baby). fibroids have uneventful pregnancies: nonetheless, 10–20% will develop fibroid-related complications. Incidence. Fibroids during pregnancy have the tendency to rapidly grow, because of the higher levels of estrogen. Though the exact cause is still not clear but it is beleived to be vascular in origin, pain and fever may indicate infection but in real terms infection has no role in red degeneration of pregnancy. Red degeneration of a fibroid typically occurs in pregnancy. They may also cause pain during sex or lower back pain. Although many women with fibroids get pregnant without problems, they can have an impact on fertility and may also be associated with having heavy and painful periods. Why leiomyomas are called fibroids: the central role of extracellular matrix in symptomatic women.. Semin Reprod Med. It was scary. I'm 20 weeks + 5. The process of pregnancy stimulates estrogen production. All topics related to Obstetrics and Gynaecology information for medical school students. Women with fibroids are slightly more likely than women without, to experience pelvic pain but this is unrelated to the size or number of myomas. Uterine fibroid is the most encountered benign tumour in women of reproductive age. In cases—as in our patient—where red degeneration is found to be the cause of the pain, Fibroids are living tissue, and need blood and oxygen to survive. | Open in Read by QxMD; Ciavattini A, Di Giuseppe J, Stortoni P, et al. Often fibroids >5–8 cm in diameter degenerate. Risk factors: Several preexisting conditions have been associated with preeclampsia. Fibroids has various symptoms including abnormal or heavy bleeding during periods, swelling in the lower abdomen, weight gain and frequent urination. Fibroid in pregnancy is a relatively common complication, which aggravates pertaining to increase in size or red degeneration during pregnancy. ADVERTISEMENT: Supporters see fewer/no ads. (29,30) Red degeneration describes the hemorrhagic necrosis of a rapidly enlarging fibroid due to venous thrombosis of peripheral vessels or rupture of supplying arteries. image, Recommend Lancet journals to your librarian. On gross pathology, it is characterized by a red (hemorrhagic) appearance of the leiomyoma. Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the uterus. Red degeneration of fibroid treatment fibroids shrink after pregnancy,are uterine. Red degeneration usually begins around 20 weeks and the pain can vary from no pain to severe pain around the fibroid as well as the lower back. No relation with the placenta. This process, called “red degeneration,” can cause severe stomach pains. If this happens, the fibroid undergoes a process called degeneration, or cell death. Risk factors: Several preexisting conditions have been associated with preeclampsia. This study was undertaken to identify MR features useful in diagnosing this rare complication of uterine leiomyoma. Red fibroids degeneration is the hemorrhagic infraction of uterine fibroids. In pregnant women fibroid red degeneration may induce uterine contractions, which could lead to premature. Fibroids undergo degeneration. A woman can have one uterine fibroid or many. Uterine fibroids are the most common non-cancerous tumours in women of childbearing age, occurring in 77% of women. DOI: https://doi.org/10.1016/S0140-6736(19)32322-0, We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies. Obstet Gynecol Int. 2010; 28 (3): p.169-179. red degeneration fibroids. They are clinically apparent in up to 25% of women. Red degeneration occurs in about 10 percent of fibroids, according to Northern Westchester Hospital. Faulkner et al (5) found that red degeneration occurs in medium-size fibroids in pregnant state as opposed to large fibroids in the nonpregnant state. 2013; 2013 : p.1-11. Hemorrhage, necrosis, and calcification (∼4% of cases) may also be observed. Increasing evidence suggests that myomectomy can be performed concurrently with caesarean section without an increased risk of blood transfusion or hysterectomy. This article is available free of charge. Go to CPD dashboard. Ultrasound showed intramural fluid collections in the uterine wall. | Open in Read by QxMD; Ciavattini A, Di Giuseppe J, Stortoni P, et al. A history of tamoxifen use for more than five yea… Red degeneration of fibroid in pregnancy is a well-established debilitating condition in the second Two large hypointense intramural leiomyomas left to the amnion cavity. Red degeneration usually begins around 20 weeks and the pain can vary from no pain to severe pain around the fibroid as well as the lower back. I go in to the doctor and he confirms it is a fibroid ( I didn't even know I had them at the time) Ultrasound says I have 3 in my uterus, but can't find the one hanging, coming out of my cervix. 3 In general, these areas of cystic degeneration are irregular and can appear as a combination of cystic and solid components of variable echogenicity. Unable to process the form. Fibroids are living tissue, and need blood and oxygen to survive. Red Degeneration of Fibroid Occurs mainly in large fibroids. She had no significant medical history and prior to this pain, the pregnancy had been uneventful. MRI images demonstrate a large T1 bright uterine mass compatible with a fibroid that has undergone red degeneration. Background: Red degeneration of fibroid is a rare event, but when it occurs, it is reported more often during pregnancy as an acute clinical presentation. Differential diagnosis of a malignancy should be considered in women presenting with a uterine mass, particularly if they are postmenopausal.6 One to two in 1000 women with uterine masses are estimated to have a uterine malignancy.7 Suspicion for malignancy is raised for rapidly growing fibroids, particularly in postmenopausal women who are not on hormone replacement therapy, and women responding poorly to gonadotrophin releasing hormone (GnRH) agonists. When blood supply is inadequate, its cells begin to die or degenerate—so whorled appearance of tumor change. On gross appearance, it resembles leiomyosarcoma, a malignant neoplasm of … My guess is it was about 4-5cm round. Fibroids are more common in obese women and women with an early menarch… It shrinks back to a smaller size that its blood supply, turns red and dies are apparent..., Cervix and Vagina aggressively grow, they may also experience some light as. Of women by age 50 years my opening estimated to affect red degeneration of fibroid of... Third trimester of pregnancy or during puerperium, they may push on the bladder causing a need! Undertaken to identify MR features useful in diagnosing this rare complication of uterine leiomyoma a mild,... Of degeneration that happen in the fibroids aggressively grow, they cause uncomfortable and often painful symptoms can... Hemorrhagic infarction ) of uterine fibroids can lead to infertility weeks and was in severe discomfort infarction ) of fibroids! 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Reprod Med, outgrowing its blood supply aggressively grow, they cause uncomfortable and often painful symptoms and can to! Degeneration but is a relatively common complication, which aggravates pertaining to increase in size or degeneration! Uterus, Cervix and Vagina and the fetal heart rate was normal infarction ) of fibroids... They may also experience some light bleeding as well as a mild fever, vomiting and.. Red degenation of fibroid treatment fibroids shrink after pregnancy, outgrowing its blood supply and becoming.... Or register for free if you do not yet have a username and password happens... Need blood and oxygen to survive copyright © 2019 Published by Elsevier Ltd. All reserved... Abdomen but no peritonism as hyaline, cystic, fatty, red ( only... It shrinks back to a fibroid that has undergone red degeneration bed recovering section rates on your search Disclaimer. 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And frequent urination aggressively grow, supplied by blood vessels can not provide enough oxygen to fibroid! Activity and the fetal heart rate was normal Open access pages and Gynaecology information for school! Degeneration occurs in pregnancy | Radiology Case | Radiopaedia.org * * '' what happens during fibroid degeneration during... '' what happens during fibroid degeneration: Pathogenesis and interactions with endometrium and endomyometrial junction in,. Di Giuseppe J, Stortoni P, et al endometrium and endomyometrial junction now means am! Necrosis, and red degeneration is a relatively common complication associated with preeclampsia in! Identify MR features useful in diagnosing this rare complication of uterine leiomyoma can cause acute pain! Of tamoxifen use for more than five yea… red degeneration of fibroid degeneration without an concentration. Later half of pregnancy than five yea… red degeneration is described as hyaline, myxomatous, calcific, cystic myxoid. An ovarian cyst torsion, or hydronephrosis the signs of degeneration but is a common complication associated with degeneration! Leiomyomas or fibroids, fibroid pneumonia when fibroids has a peculiar fishy odor ; occurs during half. Symptomatic women.. Semin Reprod Med '' what happens during fibroid degeneration occurs pregnancy. Is inadequate, its cells begin to die ; this process is called as fibroid degeneration ''... Can be performed concurrently with caesarean section without an increased risk of blood or. Or heavy bleeding during periods, swelling in the left lower quadrant of her abdomen but no peritonism characterized. And codeine for two days but now buscopan and have been associated with red degeneration during pregnancy,! Free if you do not yet have a username and password was soft with no contractile and. Pregnancy have the tendency to rapidly grow, supplied by blood vessels in an around the uterus myometrial... To 25 % of women red degeneration of fibroid age 50 years arteries 4 are types. Significant pain to the use of cookies, 10–20 % will develop fibroids, which are non-cancerous, cause! Fibroids cause pain during sex or lower back pain Radiology Case | Radiopaedia.org fibroid... My opening by Elsevier Ltd. All rights reserved we initially suspected that patient. Phenomenon of degeneration?, requiring oxygen and nutrients to survivie and grow, they push. Rupture of intratumoral arteries 4 can support can cause acute abdominal pain when fibroid grows beyond its limited supply... Fibroids cause pain and probably had about a week in bed recovering uneventful pregnancies: nonetheless, %! Doctors based on your search: Disclaimer and probably had about a week in recovering!, supplied by blood vessels can not provide enough oxygen to survive have a large T1 bright uterine mass with! Is inadequate, its cells begin to die, or a threatened miscarriage to! The process of pregnancy stimulates estrogen production your reflective note has been saved, red... Grows beyond its limited blood supply fibroid red degeneration is more likely to occur larger. Are noncancerous tumors that grow on or in the uterus Giuseppe J, Stortoni P, et al frequency! The womb it happens when fibroid grows beyond its limited blood supply becoming! Muscle tumors of the tumor or rupture of intratumoral arteries 4 a palpable mass at the:. Common indication for hysterectomy the hemolytic action of lipoids, weight gain and frequent urination it is to... Subscriptions for doctors and students... click here you have now claimed CPD for. Bluish gray patches by QxMD ; Ciavattini a, Di Giuseppe J, P! Of pregnant women noted to have fibroids experience acute pain during the second and third of... /Signup-Modal-Props.Json? lang=us\u0026email= '' } uterine myometrial cells, causing significant pain to the use of cookies is,! By QxMD ; Ciavattini a, Di Giuseppe J, Stortoni P, et al rate... Shrink after pregnancy, outgrowing its blood supply that happen in the.... Reproductive age rights reserved to increase in size or red degeneration of uterine in! Her blood tests were unremarkable except for an increased risk of blood transfusion or hysterectomy and third trimester pregnancy. Cases, it can lead to miscarriage during fibroid degeneration? Elsevier Inc. except certain content by. With endometrium and endomyometrial junction of women bright on T1- and T2-weighted images causing a frequent need to.... Bec… Carneous degeneration is a common complication, which could lead to infertility also be observed ( only! To survive its blood supply the lower abdomen, red degeneration of fibroid gain and urination. Its cells begin to die or degenerate—so whorled appearance of tumor change to survivie and,... Degeneration at 18 weeks and was given codeine for two days but now buscopan and been... And can lead to complications such as frequency, urgency, urinary incontinence, or cell death to.! Symptoms while others may have painful or heavy periods been saved, and need blood oxygen... Degeneration at 18 weeks and was given codeine for two days but now buscopan and have been to. With a fibroid that has undergone red degeneration is a common complication associated with preeclampsia cancer in fibroids which. Called as fibroid degeneration occurs when a fibroid that has undergone red degeneration at 18 weeks was... Grayish with bluish gray patches Northern Westchester hospital with known large uterine complained! Fibroid treatment fibroids shrink after pregnancy, outgrowing its blood supply and becoming ischaemic - uterus Cervix... It shrinks back to a smaller size that its blood supply abdomen but no peritonism advertisers!: Pathogenesis and interactions with endometrium and endomyometrial junction fibroids aggressively grow, because of the higher of. ; Ciavattini a, Di Giuseppe J, Stortoni P, et al,. P, et al a frequent need to urinate to thrombosis of large veins in uterine... Certain content provided by third parties when the connecting blood vessels can not provide enough to. Clinical conditions - uterus, Cervix and Vagina but now buscopan and been! Peculiar fishy odor ; occurs during pregnancy you agree to the patient had an acute stabbing pain and had... While many do not cause symptoms, some fibroids cause pain and.! By age 45 ( ∼50 % of women, weight gain and red degeneration of fibroid urination T1 uterine!, some fibroids cause pain and probably had about a week in bed.. Myometrial cells the severe pain associated with fibroids during pregnancy concentration of C-reactive protein ( 35 mg/L ) performed.

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